When I ran a bench of 4 gigs @ 1066 5-5-5-15, and another bench @ 800 4-4-4-12, There was only a small difference. A few hundred points if that, probably not even noticeable for gaming etc, Running it at the slower speed it benched less for my setup.
I would bow to the I7 users here for the input at those speeds and timings. But I don't think the difference is going to be huge. For the increase in speed will be matched with slower timing. So one would surmise the difference would be marginal.
http://www.tomshardware.com/reviews/mem ... 25-11.html